Substrate-derived Sortase A inhibitors: targeting an essential virulence factor of Gram-positive pathogenic bacteria

The bacterial transpeptidase Sortase A (SrtA) is a surface enzyme of Gram-positive pathogenic bacteria. It has been shown to be an essential virulence factor for the establishment of various bacterial infections, including septic arthritis. However, the development of potent Sortase A inhibitors rem...

Descripción completa

Detalles Bibliográficos
Autores principales: Abujubara, Helal, Hintzen, Jordi C. J., Rahimi, Shadi, Mijakovic, Ivan, Tietze, Daniel, Tietze, Alesia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306101/
https://www.ncbi.nlm.nih.gov/pubmed/37389257
http://dx.doi.org/10.1039/d3sc01209c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306101/
https://www.ncbi.nlm.nih.gov/pubmed/37389257
http://dx.doi.org/10.1039/d3sc01209c

Ejemplares similares