Stereoselective two-carbon ring expansion of allylic amines via electronic control of palladium-promoted equilibria

General methodologies enabling the two-carbon homologation of pyrrolidine and piperidine systems have yet to be developed. Herein we report that palladium-catalysed allylic amine rearrangements enable efficient two-carbon ring expansion of 2-alkenyl pyrrolidine and piperidines to their azepane and a...

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Detalles Bibliográficos
Autores principales: Mikan, Charles P., Matthews, Aidan, Harris, Daniel, McIvor, Charlotte E., Waddell, Paul G., Sims, Mark T., Knowles, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306103/
https://www.ncbi.nlm.nih.gov/pubmed/37389260
http://dx.doi.org/10.1039/d3sc02303f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306103/
https://www.ncbi.nlm.nih.gov/pubmed/37389260
http://dx.doi.org/10.1039/d3sc02303f

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