Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition

Individuals with Down syndrome (DS) display chronic hyperactivation of interferon signaling. However, the clinical impacts of interferon hyperactivity in DS are ill-defined. Here, we describe a multiomics investigation of interferon signaling in hundreds of individuals with DS. Using interferon scor...

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Detalles Bibliográficos
Autores principales: Galbraith, Matthew D., Rachubinski, Angela L., Smith, Keith P., Araya, Paula, Waugh, Katherine A., Enriquez-Estrada, Belinda, Worek, Kayleigh, Granrath, Ross E., Kinning, Kohl T., Paul Eduthan, Neetha, Ludwig, Michael P., Hsieh, Elena W. Y., Sullivan, Kelly D., Espinosa, Joaquin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306300/
https://www.ncbi.nlm.nih.gov/pubmed/37379383
http://dx.doi.org/10.1126/sciadv.adg6218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306300/
https://www.ncbi.nlm.nih.gov/pubmed/37379383
http://dx.doi.org/10.1126/sciadv.adg6218

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