Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities

The degradation tag (dTAG) system for target protein degradation can remove proteins from biological systems without the drawbacks of some genetic methods, such as slow kinetics, lack of reversibility, low specificity, and the inability to titrate dosage. These drawbacks can make it difficult to com...

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Detalles Bibliográficos
Autores principales: Yenerall, Paul, Sung, Tae, Palyada, Kiran, Qian, Jessie, Arat, Seda, Kumpf, Steven W, Wang, Shih-Wen, Biddle, Kathleen, Esparza, Carlos, Chang, Stephanie, Scott, Wesley, Collette, Walter, Winrow, Taylor-Symon, Affolter, Tim, Shirai, Norimitsu, Thibault, Stephane, Wang, Julia, Liu, Ling, Bauchmann, Mary, Frey, Jessica, Steyn, Stefanus, Sacaan, Aida, Vitsky, Allison, Ahn, Youngwook, Paul, Tom, Lum, Lawrence, Oyer, Jon, Yang, Amy, Hu, Wenyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Emerging Technologies, Methods, and Models
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306401/
https://www.ncbi.nlm.nih.gov/pubmed/37228089
http://dx.doi.org/10.1093/toxsci/kfad049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306401/
https://www.ncbi.nlm.nih.gov/pubmed/37228089
http://dx.doi.org/10.1093/toxsci/kfad049

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