Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

Plasma membrane rupture (PMR) in dying cells undergoing pyroptosis or apoptosis requires the cell-surface protein NINJ1(1). PMR releases pro-inflammatory cytoplasmic molecules, collectively called damage-associated molecular patterns (DAMPs), that activate immune cells. Therefore, inhibiting NINJ1 a...

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Detalles Bibliográficos
Autores principales: Kayagaki, Nobuhiko, Stowe, Irma B., Alegre, Kamela, Deshpande, Ishan, Wu, Shuang, Lin, Zhonghua, Kornfeld, Opher S., Lee, Bettina L., Zhang, Juan, Liu, John, Suto, Eric, Lee, Wyne P., Schneider, Kellen, Lin, WeiYu, Seshasayee, Dhaya, Bhangale, Tushar, Chalouni, Cecile, Johnson, Matthew C., Joshi, Prajakta, Mossemann, Jan, Zhao, Sarah, Ali, Danish, Goldenberg, Neil M., Sayed, Blayne A., Steinberg, Benjamin E., Newton, Kim, Webster, Joshua D., Kelly, Ryan L., Dixit, Vishva M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307625/
https://www.ncbi.nlm.nih.gov/pubmed/37196676
http://dx.doi.org/10.1038/s41586-023-06191-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307625/
https://www.ncbi.nlm.nih.gov/pubmed/37196676
http://dx.doi.org/10.1038/s41586-023-06191-5

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