Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis

Kidney metabolism may be greatly altered in chronic kidney disease. Here we report that arginine metabolism is the most altered in unilateral ureteral obstruction (UUO)-induced fibrosis of the kidneys in metabolomic analysis. Spermidine is the most increased metabolite of arginine. In human glomerul...

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Detalles Bibliográficos
Autores principales: Aihara, Seishi, Torisu, Kumiko, Uchida, Yushi, Imazu, Noriyuki, Nakano, Toshiaki, Kitazono, Takanari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307812/
https://www.ncbi.nlm.nih.gov/pubmed/37380734
http://dx.doi.org/10.1038/s42003-023-05057-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307812/
https://www.ncbi.nlm.nih.gov/pubmed/37380734
http://dx.doi.org/10.1038/s42003-023-05057-w

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