Narcolepsy type I-associated DNA methylation and gene expression changes in the human leukocyte antigen region

Narcolepsy type 1 (NT1) is caused by a loss of hypothalamic orexin-producing cells, and autoreactive CD4(+) and CD8(+) T cells have been suggested to play a role in the autoimmune mechanism. Although NT1 showed a strong association with human leukocyte antigen (HLA)-DQB1*06:02, the responsible antig...

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Detalles Bibliográficos
Autores principales: Yoshida-Tanaka, Kugui, Shimada, Mihoko, Honda, Yoshiko, Fujimoto, Akihiro, Tokunaga, Katsushi, Honda, Makoto, Miyagawa, Taku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307834/
https://www.ncbi.nlm.nih.gov/pubmed/37380713
http://dx.doi.org/10.1038/s41598-023-37511-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307834/
https://www.ncbi.nlm.nih.gov/pubmed/37380713
http://dx.doi.org/10.1038/s41598-023-37511-4

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