Development of a human malaria-on-a-chip disease model for drug efficacy and off-target toxicity evaluation

A functional, multi-organ, serum-free system was developed for the culture of P. falciparum in an attempt to establish innovative platforms for therapeutic drug development. It contains 4 human organ constructs including hepatocytes, splenocytes, endothelial cells, as well as recirculating red blood...

Descripción completa

Detalles Bibliográficos
Autores principales: Rupar, Michael J., Sasserath, Trevor, Smith, Ethan, Comiter, Brandon, Sriram, Narasimhan, Long, Christopher J., McAleer, Christopher W., Hickman, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307889/
https://www.ncbi.nlm.nih.gov/pubmed/37380653
http://dx.doi.org/10.1038/s41598-023-35694-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307889/
https://www.ncbi.nlm.nih.gov/pubmed/37380653
http://dx.doi.org/10.1038/s41598-023-35694-4

Ejemplares similares