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Development of a human malaria-on-a-chip disease model for drug efficacy and off-target toxicity evaluation

A functional, multi-organ, serum-free system was developed for the culture of P. falciparum in an attempt to establish innovative platforms for therapeutic drug development. It contains 4 human organ constructs including hepatocytes, splenocytes, endothelial cells, as well as recirculating red blood...

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Detalles Bibliográficos
Autores principales:	Rupar, Michael J., Sasserath, Trevor, Smith, Ethan, Comiter, Brandon, Sriram, Narasimhan, Long, Christopher J., McAleer, Christopher W., Hickman, James J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307889/ https://www.ncbi.nlm.nih.gov/pubmed/37380653 http://dx.doi.org/10.1038/s41598-023-35694-4

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