FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels

Selective autophagy of mitochondria, mitophagy, is linked to mitochondrial quality control and as such is critical to a healthy organism. We have used a CRISPR/Cas9 approach to screen human E3 ubiquitin ligases for influence on mitophagy under both basal cell culture conditions and upon acute mitoch...

Descripción completa

Detalles Bibliográficos
Autores principales: Elcocks, Hannah, Brazel, Ailbhe J, McCarron, Katy R, Kaulich, Manuel, Husnjak, Koraljka, Mortiboys, Heather, Clague, Michael J, Urbé, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308357/
https://www.ncbi.nlm.nih.gov/pubmed/37102372
http://dx.doi.org/10.15252/embj.2022112799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308357/
https://www.ncbi.nlm.nih.gov/pubmed/37102372
http://dx.doi.org/10.15252/embj.2022112799

Ejemplares similares