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A pH‑responsive hyaluronic acid nano‑vehicle co‑encapsulating doxorubicin and all‑trans retinoic acid for the inhibition of hepatic stellate cell‑induced tumor growth and metastasis

All-trans retinoic acid (ATRA) has been implicated in the differentiation of hepatic stellate cells (HSCs). In the present study, the liver-targeting hyaluronic acid micelles (ADHG) were prepared for co-delivery of ATRA and doxorubicin (DOX) to block the HSC-hepatoma interrelation. To simulate the t...

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Detalles Bibliográficos
Autores principales: Lu, Qiao, Gong, Xueyang, Jia, Guangtao, Wu, Jingliang, Liu, Siwei, Song, Ke, Tian, Guixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308492/
https://www.ncbi.nlm.nih.gov/pubmed/37326031
http://dx.doi.org/10.3892/mmr.2023.13029