Molecular Dynamics-Based Design and Biophysical Evaluation of Thermostable Single-Chain Fv Antibody Mutants Derived from Pharmaceutical Antibodies

[Image: see text] Antibody drugs are denatured under physical stress, e.g., friction, heat, and freezing, which triggers formation of aggregates and resultant allergic reactions. Design of a stable antibody is thus critical for the development of antibody drugs. Here, we obtained a thermostable sing...

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Detalles Bibliográficos
Autores principales: Okazaki, Kyo, Kobashigawa, Yoshihiro, Morita, Hikari, Yamauchi, Soichiro, Fukuda, Natsuki, Liu, Chenjiang, Toyota, Yuya, Sato, Takashi, Morioka, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308585/
https://www.ncbi.nlm.nih.gov/pubmed/37396255
http://dx.doi.org/10.1021/acsomega.3c01948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308585/
https://www.ncbi.nlm.nih.gov/pubmed/37396255
http://dx.doi.org/10.1021/acsomega.3c01948

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