Design and generation of mRNAs encoding conserved regions of SARS-CoV-2 ORF1ab for T cell-mediated immune activation

AIM: To generate mRNAs encoding conserved regions within SARS-CoV-2 ORF1ab which can induce strong T-cell responses to overcome the immune invasion of newly emergent variants. METHODS: We selected two conserved regions with a high density of T-cell epitopes using immunoinformatics for mRNA synthesis...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Cao Minh, Luong, Bac An, Thi Tran, Thu Thuy, Nguyen, Hoai Nghia, Tran, Le Son
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308627/
http://dx.doi.org/10.2217/fvl-2023-0066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308627/
http://dx.doi.org/10.2217/fvl-2023-0066

Ejemplares similares