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Design and generation of mRNAs encoding conserved regions of SARS-CoV-2 ORF1ab for T cell-mediated immune activation

AIM: To generate mRNAs encoding conserved regions within SARS-CoV-2 ORF1ab which can induce strong T-cell responses to overcome the immune invasion of newly emergent variants. METHODS: We selected two conserved regions with a high density of T-cell epitopes using immunoinformatics for mRNA synthesis...

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Detalles Bibliográficos
Autores principales:	Nguyen, Cao Minh, Luong, Bac An, Thi Tran, Thu Thuy, Nguyen, Hoai Nghia, Tran, Le Son
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Future Medicine Ltd 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308627/ http://dx.doi.org/10.2217/fvl-2023-0066

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