A novel camptothecin derivative, ZBH-01, exhibits superior antitumor efficacy than irinotecan by regulating the cell cycle

BACKGROUND: Irinotecan (CPT-11) is a classic chemotherapeutic agent that plays an important role in the clinical treatment of metastatic colon cancer and other malignant tumors. We previously designed a series of novel irinotecan derivatives. In this study, we select one representative, ZBH-01, to i...

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Detalles Bibliográficos
Autores principales: Li, Yongqi, Zhao, Dawei, Zhang, Wenqiu, Yang, Miaomiao, Wu, Zhihui, Shi, Weiguo, Lan, Shijie, Guo, Zhen, Yu, Hong, Wu, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308760/
https://www.ncbi.nlm.nih.gov/pubmed/37386467
http://dx.doi.org/10.1186/s12967-023-04196-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308760/
https://www.ncbi.nlm.nih.gov/pubmed/37386467
http://dx.doi.org/10.1186/s12967-023-04196-2

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