Conserved Characteristics of NMPylation Activities of Alpha- and Betacoronavirus NiRAN Domains

Coronavirus genome replication and expression are mediated by the viral replication-transcription complex (RTC) which is assembled from multiple nonstructural proteins (nsp). Among these, nsp12 represents the central functional subunit. It harbors the RNA-directed RNA polymerase (RdRp) domain and co...

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Detalles Bibliográficos
Autores principales: Slanina, Heiko, Madhugiri, Ramakanth, Wenk, Kai, Reinke, Tess, Schultheiß, Karin, Schultheis, Julia, Karl, Nadja, Linne, Uwe, Ziebuhr, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308930/
https://www.ncbi.nlm.nih.gov/pubmed/37199624
http://dx.doi.org/10.1128/jvi.00465-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308930/
https://www.ncbi.nlm.nih.gov/pubmed/37199624
http://dx.doi.org/10.1128/jvi.00465-23

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