Licraside as novel potent FXR agonist for relieving cholestasis: structure-based drug discovery and biological evaluation studies

Cholestasis is a common clinical disease caused by a disorder in bile acids (BAs) homeostasis, which promotes its development. The Farnesoid X receptor (FXR) plays a critical role in regulating BAs homeostasis, making it an essential target for cholestasis treatment. Although several active FXR agon...

Descripción completa

Detalles Bibliográficos
Autores principales: Xi, Lili, Shi, Axi, Shen, Tiantian, Wang, Guoxu, Wei, Yuhui, Guo, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309033/
https://www.ncbi.nlm.nih.gov/pubmed/37397498
http://dx.doi.org/10.3389/fphar.2023.1197856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309033/
https://www.ncbi.nlm.nih.gov/pubmed/37397498
http://dx.doi.org/10.3389/fphar.2023.1197856

Ejemplares similares