Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury

BACKGROUND: Dysfunction of the gap junction channel protein connexin 43 (Cx43) contributes to myocardial ischemia/reperfusion (I/R)-induced ventricular arrhythmias. Cx43 can be regulated by small ubiquitin-like modifier (SUMO) modification. Protein inhibitor of activated STAT Y (PIASy) is an E3 SUMO...

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Detalles Bibliográficos
Autores principales: Wang, Tingting, Liu, Jinmin, Hu, Chenchen, Wei, Xin, Han, Linlin, Zhu, Afang, Wang, Rong, Chen, Zhijun, Xia, Zhengyuan, Yao, Shanglong, Mao, Weike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309519/
https://www.ncbi.nlm.nih.gov/pubmed/37014755
http://dx.doi.org/10.1097/CM9.0000000000002618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309519/
https://www.ncbi.nlm.nih.gov/pubmed/37014755
http://dx.doi.org/10.1097/CM9.0000000000002618

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