Integration of a Cross-Ancestry Polygenic Model With Clinical Risk Factors Improves Breast Cancer Risk Stratification

To develop and validate a cross-ancestry integrated risk score (caIRS) that combines a cross-ancestry polygenic risk score (caPRS) with a clinical estimator for breast cancer (BC) risk. We hypothesized that the caIRS is a better predictor of BC risk than clinical risk factors across diverse ancestry...

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Detalles Bibliográficos
Autores principales: Tshiaba, Placede T., Ratman, Dariusz K., Sun, Jiayi M., Tunstall, Tate S., Levy, Brynn, Shah, Premal S., Weitzel, Jeffrey N., Rabinowitz, Matthew, Kumar, Akash, Im, Kate M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2023
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309538/
https://www.ncbi.nlm.nih.gov/pubmed/36809055
http://dx.doi.org/10.1200/PO.22.00447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309538/
https://www.ncbi.nlm.nih.gov/pubmed/36809055
http://dx.doi.org/10.1200/PO.22.00447

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