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Myc promotes polyploidy in murine trophoblast cells and suppresses senescence

The placenta is essential for reproductive success. The murine placenta includes polyploid giant cells that are crucial for its function. Polyploidy occurs broadly in nature but its regulators and significance in the placenta are unknown. We have discovered that many murine placental cell types are...

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Detalles Bibliográficos
Autores principales: Singh, Vijay Pratap, Hassan, Huzaifa, Deng, Fengyan, Tsuchiya, Dai, McKinney, Sean, Ferro, Kevin, Gerton, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309589/
https://www.ncbi.nlm.nih.gov/pubmed/37278344
http://dx.doi.org/10.1242/dev.201581