A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain

Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host–pathogen interactions and...

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Autores principales: Muhi, Stephen, Osowicki, Joshua, O’Brien, Daniel, Johnson, Paul D. R., Pidot, Sacha, Doerflinger, Marcel, Marshall, Julia L., Pellegrini, Marc, McCarthy, James, Stinear, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309606/
https://www.ncbi.nlm.nih.gov/pubmed/37384606
http://dx.doi.org/10.1371/journal.pntd.0011394
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author Muhi, Stephen
Osowicki, Joshua
O’Brien, Daniel
Johnson, Paul D. R.
Pidot, Sacha
Doerflinger, Marcel
Marshall, Julia L.
Pellegrini, Marc
McCarthy, James
Stinear, Timothy P.
author_facet Muhi, Stephen
Osowicki, Joshua
O’Brien, Daniel
Johnson, Paul D. R.
Pidot, Sacha
Doerflinger, Marcel
Marshall, Julia L.
Pellegrini, Marc
McCarthy, James
Stinear, Timothy P.
author_sort Muhi, Stephen
collection PubMed
description Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host–pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.
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spelling pubmed-103096062023-06-30 A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain Muhi, Stephen Osowicki, Joshua O’Brien, Daniel Johnson, Paul D. R. Pidot, Sacha Doerflinger, Marcel Marshall, Julia L. Pellegrini, Marc McCarthy, James Stinear, Timothy P. PLoS Negl Trop Dis Review Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host–pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain. Public Library of Science 2023-06-29 /pmc/articles/PMC10309606/ /pubmed/37384606 http://dx.doi.org/10.1371/journal.pntd.0011394 Text en © 2023 Muhi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Muhi, Stephen
Osowicki, Joshua
O’Brien, Daniel
Johnson, Paul D. R.
Pidot, Sacha
Doerflinger, Marcel
Marshall, Julia L.
Pellegrini, Marc
McCarthy, James
Stinear, Timothy P.
A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain
title A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain
title_full A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain
title_fullStr A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain
title_full_unstemmed A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain
title_short A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain
title_sort human model of buruli ulcer: the case for controlled human infection and considerations for selecting a mycobacterium ulcerans challenge strain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309606/
https://www.ncbi.nlm.nih.gov/pubmed/37384606
http://dx.doi.org/10.1371/journal.pntd.0011394
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