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B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review

Intramedullary tumors represent the major cause of spinal cord injuries, and its symptoms include pain and weakness. Progressive weakness may concomitantly occur in the upper and lower limbs, along with lack of balance, spine tenderness, sensory loss, trophic changes of extremity, hyperreflexia, and...

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Autores principales: Gonsalves, Daniel Gregório, Raffa, Paulo Eduardo Albuquerque Zito, de Sousa, Gabriela Gerenutti, Rigueiral, Melissa Esposito Gomes, Estevão, Iracema Araújo, Pacheco, Cesar Cozar, Medeiros, Roger Thomaz Rotta, Franceschini, Paulo Roberto, de Aguiar, Paulo Henrique Pires
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310451/
https://www.ncbi.nlm.nih.gov/pubmed/37397032
http://dx.doi.org/10.1055/s-0043-1768574
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author Gonsalves, Daniel Gregório
Raffa, Paulo Eduardo Albuquerque Zito
de Sousa, Gabriela Gerenutti
Rigueiral, Melissa Esposito Gomes
Estevão, Iracema Araújo
Pacheco, Cesar Cozar
Medeiros, Roger Thomaz Rotta
Franceschini, Paulo Roberto
de Aguiar, Paulo Henrique Pires
author_facet Gonsalves, Daniel Gregório
Raffa, Paulo Eduardo Albuquerque Zito
de Sousa, Gabriela Gerenutti
Rigueiral, Melissa Esposito Gomes
Estevão, Iracema Araújo
Pacheco, Cesar Cozar
Medeiros, Roger Thomaz Rotta
Franceschini, Paulo Roberto
de Aguiar, Paulo Henrique Pires
author_sort Gonsalves, Daniel Gregório
collection PubMed
description Intramedullary tumors represent the major cause of spinal cord injuries, and its symptoms include pain and weakness. Progressive weakness may concomitantly occur in the upper and lower limbs, along with lack of balance, spine tenderness, sensory loss, trophic changes of extremity, hyperreflexia, and clonus. The study protocol was in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A systematic search of the MEDLINE electronic database was performed to identify the studies reporting the clinical features of children and adults who presented with an intramedullary lymphoma. Twenty-one studies were included, reporting 25 cases. Manuscripts were excluded if the full-text article was not available, original data were not reported (e.g., review articles), or if the main disease was not intramedullary lymphoma. A structured data extraction form was employed to standardize the identification and retrieval of data from manuscripts. To enlighten the discussion, a case is also presented. An 82-year-old woman with Fitzpatrick skin type II, diagnosed and treated for non-Hodgkin's lymphoma 7 years ago, was admitted with mental confusion and memory loss for the past 2 months—evolving with recurring falls from her own height. One day before admission, she displayed Brown-Séquard syndrome. An expansive lesion from C2 to C4 in the cervical spinal cord was found and a hypersignal spinal cord adjacent was described at the bulb medullary transition to the C6–C7 level. A primary spinal cord tumor was considered, as well as a melanoma metastasis, due to the lesion's flame pattern. The patient presented a partial recovery of symptoms and a reduction of the spinal cord edema after being empirically treated with corticosteroids, but the lesion maintained its extent. Subsequently, a large diffuse B-cell lymphoma with nongerminal center was found in open body biopsy, infiltrating neural tissue. The main objective of the present study is to report a surgical case treated for a large diffuse B-cell lymphoma, in addition to presenting the results of a systematic review of primary intramedullary spinal cord lymphoma.
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spelling pubmed-103104512023-06-30 B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review Gonsalves, Daniel Gregório Raffa, Paulo Eduardo Albuquerque Zito de Sousa, Gabriela Gerenutti Rigueiral, Melissa Esposito Gomes Estevão, Iracema Araújo Pacheco, Cesar Cozar Medeiros, Roger Thomaz Rotta Franceschini, Paulo Roberto de Aguiar, Paulo Henrique Pires Asian J Neurosurg Intramedullary tumors represent the major cause of spinal cord injuries, and its symptoms include pain and weakness. Progressive weakness may concomitantly occur in the upper and lower limbs, along with lack of balance, spine tenderness, sensory loss, trophic changes of extremity, hyperreflexia, and clonus. The study protocol was in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A systematic search of the MEDLINE electronic database was performed to identify the studies reporting the clinical features of children and adults who presented with an intramedullary lymphoma. Twenty-one studies were included, reporting 25 cases. Manuscripts were excluded if the full-text article was not available, original data were not reported (e.g., review articles), or if the main disease was not intramedullary lymphoma. A structured data extraction form was employed to standardize the identification and retrieval of data from manuscripts. To enlighten the discussion, a case is also presented. An 82-year-old woman with Fitzpatrick skin type II, diagnosed and treated for non-Hodgkin's lymphoma 7 years ago, was admitted with mental confusion and memory loss for the past 2 months—evolving with recurring falls from her own height. One day before admission, she displayed Brown-Séquard syndrome. An expansive lesion from C2 to C4 in the cervical spinal cord was found and a hypersignal spinal cord adjacent was described at the bulb medullary transition to the C6–C7 level. A primary spinal cord tumor was considered, as well as a melanoma metastasis, due to the lesion's flame pattern. The patient presented a partial recovery of symptoms and a reduction of the spinal cord edema after being empirically treated with corticosteroids, but the lesion maintained its extent. Subsequently, a large diffuse B-cell lymphoma with nongerminal center was found in open body biopsy, infiltrating neural tissue. The main objective of the present study is to report a surgical case treated for a large diffuse B-cell lymphoma, in addition to presenting the results of a systematic review of primary intramedullary spinal cord lymphoma. Thieme Medical and Scientific Publishers Pvt. Ltd. 2023-06-06 /pmc/articles/PMC10310451/ /pubmed/37397032 http://dx.doi.org/10.1055/s-0043-1768574 Text en Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Gonsalves, Daniel Gregório
Raffa, Paulo Eduardo Albuquerque Zito
de Sousa, Gabriela Gerenutti
Rigueiral, Melissa Esposito Gomes
Estevão, Iracema Araújo
Pacheco, Cesar Cozar
Medeiros, Roger Thomaz Rotta
Franceschini, Paulo Roberto
de Aguiar, Paulo Henrique Pires
B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review
title B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review
title_full B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review
title_fullStr B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review
title_full_unstemmed B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review
title_short B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review
title_sort b-cell lymphoma intramedullary tumor: case report and systematic review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310451/
https://www.ncbi.nlm.nih.gov/pubmed/37397032
http://dx.doi.org/10.1055/s-0043-1768574
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