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B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review
Intramedullary tumors represent the major cause of spinal cord injuries, and its symptoms include pain and weakness. Progressive weakness may concomitantly occur in the upper and lower limbs, along with lack of balance, spine tenderness, sensory loss, trophic changes of extremity, hyperreflexia, and...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310451/ https://www.ncbi.nlm.nih.gov/pubmed/37397032 http://dx.doi.org/10.1055/s-0043-1768574 |
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author | Gonsalves, Daniel Gregório Raffa, Paulo Eduardo Albuquerque Zito de Sousa, Gabriela Gerenutti Rigueiral, Melissa Esposito Gomes Estevão, Iracema Araújo Pacheco, Cesar Cozar Medeiros, Roger Thomaz Rotta Franceschini, Paulo Roberto de Aguiar, Paulo Henrique Pires |
author_facet | Gonsalves, Daniel Gregório Raffa, Paulo Eduardo Albuquerque Zito de Sousa, Gabriela Gerenutti Rigueiral, Melissa Esposito Gomes Estevão, Iracema Araújo Pacheco, Cesar Cozar Medeiros, Roger Thomaz Rotta Franceschini, Paulo Roberto de Aguiar, Paulo Henrique Pires |
author_sort | Gonsalves, Daniel Gregório |
collection | PubMed |
description | Intramedullary tumors represent the major cause of spinal cord injuries, and its symptoms include pain and weakness. Progressive weakness may concomitantly occur in the upper and lower limbs, along with lack of balance, spine tenderness, sensory loss, trophic changes of extremity, hyperreflexia, and clonus. The study protocol was in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A systematic search of the MEDLINE electronic database was performed to identify the studies reporting the clinical features of children and adults who presented with an intramedullary lymphoma. Twenty-one studies were included, reporting 25 cases. Manuscripts were excluded if the full-text article was not available, original data were not reported (e.g., review articles), or if the main disease was not intramedullary lymphoma. A structured data extraction form was employed to standardize the identification and retrieval of data from manuscripts. To enlighten the discussion, a case is also presented. An 82-year-old woman with Fitzpatrick skin type II, diagnosed and treated for non-Hodgkin's lymphoma 7 years ago, was admitted with mental confusion and memory loss for the past 2 months—evolving with recurring falls from her own height. One day before admission, she displayed Brown-Séquard syndrome. An expansive lesion from C2 to C4 in the cervical spinal cord was found and a hypersignal spinal cord adjacent was described at the bulb medullary transition to the C6–C7 level. A primary spinal cord tumor was considered, as well as a melanoma metastasis, due to the lesion's flame pattern. The patient presented a partial recovery of symptoms and a reduction of the spinal cord edema after being empirically treated with corticosteroids, but the lesion maintained its extent. Subsequently, a large diffuse B-cell lymphoma with nongerminal center was found in open body biopsy, infiltrating neural tissue. The main objective of the present study is to report a surgical case treated for a large diffuse B-cell lymphoma, in addition to presenting the results of a systematic review of primary intramedullary spinal cord lymphoma. |
format | Online Article Text |
id | pubmed-10310451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103104512023-06-30 B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review Gonsalves, Daniel Gregório Raffa, Paulo Eduardo Albuquerque Zito de Sousa, Gabriela Gerenutti Rigueiral, Melissa Esposito Gomes Estevão, Iracema Araújo Pacheco, Cesar Cozar Medeiros, Roger Thomaz Rotta Franceschini, Paulo Roberto de Aguiar, Paulo Henrique Pires Asian J Neurosurg Intramedullary tumors represent the major cause of spinal cord injuries, and its symptoms include pain and weakness. Progressive weakness may concomitantly occur in the upper and lower limbs, along with lack of balance, spine tenderness, sensory loss, trophic changes of extremity, hyperreflexia, and clonus. The study protocol was in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A systematic search of the MEDLINE electronic database was performed to identify the studies reporting the clinical features of children and adults who presented with an intramedullary lymphoma. Twenty-one studies were included, reporting 25 cases. Manuscripts were excluded if the full-text article was not available, original data were not reported (e.g., review articles), or if the main disease was not intramedullary lymphoma. A structured data extraction form was employed to standardize the identification and retrieval of data from manuscripts. To enlighten the discussion, a case is also presented. An 82-year-old woman with Fitzpatrick skin type II, diagnosed and treated for non-Hodgkin's lymphoma 7 years ago, was admitted with mental confusion and memory loss for the past 2 months—evolving with recurring falls from her own height. One day before admission, she displayed Brown-Séquard syndrome. An expansive lesion from C2 to C4 in the cervical spinal cord was found and a hypersignal spinal cord adjacent was described at the bulb medullary transition to the C6–C7 level. A primary spinal cord tumor was considered, as well as a melanoma metastasis, due to the lesion's flame pattern. The patient presented a partial recovery of symptoms and a reduction of the spinal cord edema after being empirically treated with corticosteroids, but the lesion maintained its extent. Subsequently, a large diffuse B-cell lymphoma with nongerminal center was found in open body biopsy, infiltrating neural tissue. The main objective of the present study is to report a surgical case treated for a large diffuse B-cell lymphoma, in addition to presenting the results of a systematic review of primary intramedullary spinal cord lymphoma. Thieme Medical and Scientific Publishers Pvt. Ltd. 2023-06-06 /pmc/articles/PMC10310451/ /pubmed/37397032 http://dx.doi.org/10.1055/s-0043-1768574 Text en Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Gonsalves, Daniel Gregório Raffa, Paulo Eduardo Albuquerque Zito de Sousa, Gabriela Gerenutti Rigueiral, Melissa Esposito Gomes Estevão, Iracema Araújo Pacheco, Cesar Cozar Medeiros, Roger Thomaz Rotta Franceschini, Paulo Roberto de Aguiar, Paulo Henrique Pires B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review |
title | B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review |
title_full | B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review |
title_fullStr | B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review |
title_full_unstemmed | B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review |
title_short | B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review |
title_sort | b-cell lymphoma intramedullary tumor: case report and systematic review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310451/ https://www.ncbi.nlm.nih.gov/pubmed/37397032 http://dx.doi.org/10.1055/s-0043-1768574 |
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