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Discovery of highly immunogenic spleen-resident FCGR3(+)CD103(+) cDC1s differentiated by IL-33-primed ST2(+) basophils

Recombinant interleukin-33 (IL-33) inhibits tumor growth, but the detailed immunological mechanism is still unknown. IL-33-mediated tumor suppression did not occur in Batf3(−/−) mice, indicating that conventional type 1 dendritic cells (cDC1s) play a key role in IL-33-mediated antitumor immunity. A...

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Detalles Bibliográficos
Autores principales: Kang, Myeong-Ho, Hong, JungHyub, Lee, Jinjoo, Cha, Min-Suk, Lee, Sangho, Kim, Hye-Young, Ha, Sang-Jun, Lim, Yong Taik, Bae, Yong-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310784/
https://www.ncbi.nlm.nih.gov/pubmed/37246159
http://dx.doi.org/10.1038/s41423-023-01035-8