Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation

Among all cancers, colorectal cancer (CRC) is the 3rd most common and the 2nd leading cause of death worldwide. New therapeutic strategies are required to target cancer stem cells (CSCs), a subset of tumor cells highly resistant to present-day therapy and responsible for tumor relapse. CSCs display...

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Detalles Bibliográficos
Autores principales: Antona, Annamaria, Leo, Giovanni, Favero, Francesco, Varalda, Marco, Venetucci, Jacopo, Faletti, Stefania, Todaro, Matilde, Mazzucco, Eleonora, Soligo, Enrica, Saglietti, Chiara, Stassi, Giorgio, Manfredi, Marcello, Pelicci, Giuliana, Corà, Davide, Valente, Guido, Capello, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310788/
https://www.ncbi.nlm.nih.gov/pubmed/37385999
http://dx.doi.org/10.1038/s41420-023-01502-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310788/
https://www.ncbi.nlm.nih.gov/pubmed/37385999
http://dx.doi.org/10.1038/s41420-023-01502-1

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