Cargando…

Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation

Among all cancers, colorectal cancer (CRC) is the 3rd most common and the 2nd leading cause of death worldwide. New therapeutic strategies are required to target cancer stem cells (CSCs), a subset of tumor cells highly resistant to present-day therapy and responsible for tumor relapse. CSCs display...

Descripción completa

Detalles Bibliográficos
Autores principales:	Antona, Annamaria, Leo, Giovanni, Favero, Francesco, Varalda, Marco, Venetucci, Jacopo, Faletti, Stefania, Todaro, Matilde, Mazzucco, Eleonora, Soligo, Enrica, Saglietti, Chiara, Stassi, Giorgio, Manfredi, Marcello, Pelicci, Giuliana, Corà, Davide, Valente, Guido, Capello, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310788/ https://www.ncbi.nlm.nih.gov/pubmed/37385999 http://dx.doi.org/10.1038/s41420-023-01502-1

Ejemplares similares

Targeting Histone Demethylase LSD1/KDM1a in Neurodegenerative Diseases
por: Ambrosio, Susanna, et al.
Publicado: (2018)

The histone demethylase LSD1/KDM1A promotes the DNA damage response
por: Mosammaparast, Nima, et al.
Publicado: (2013)

Lysine-Specific Demethylase 1 (LSD1/KDM1A) Inhibition as a Target for Disease Modification in Myelofibrosis
por: Gill, Harinder
Publicado: (2022)

Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma
por: Amente, Stefano, et al.
Publicado: (2015)

Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A
por: Cuyàs, Elisabet, et al.
Publicado: (2019)

Functional characterization of lysine-specific demethylase 2 (LSD2/KDM1B) in breast cancer progression
por: Chen, Lin, et al.
Publicado: (2017)

Deletion of histone demethylase Lsd1 (Kdm1a) during retinal development leads to defects in retinal function and structure
por: Ferdous, Salma, et al.
Publicado: (2023)

Activation of HIV Transcription by the Viral Tat Protein Requires a Demethylation Step Mediated by Lysine-specific Demethylase 1 (LSD1/KDM1)
por: Sakane, Naoki, et al.
Publicado: (2011)

Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A)
por: Li, Zhonghua, et al.
Publicado: (2019)

UPO Biobank: The Challenge of Integrating Biobanking into the Academic Environment to Support Translational Research
por: Bettio, Valentina, et al.
Publicado: (2023)

Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer
por: Antona, Annamaria, et al.
Publicado: (2022)

Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases
por: Kim, Dongha, et al.
Publicado: (2021)

Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation
por: Xiong, Yujing, et al.
Publicado: (2016)

LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer
por: Jotatsu, Takanobu, et al.
Publicado: (2016)

RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1
por: Xu, Tao, et al.
Publicado: (2017)

KDM1A/LSD1 regulates the differentiation and maintenance of spermatogonia in mice
por: Myrick, Dexter A., et al.
Publicado: (2017)

LSD1/KDM1A inhibitors in clinical trials: advances and prospects
por: Fang, Yuan, et al.
Publicado: (2019)

Correction: Gill, H. Lysine-Specific Demethylase 1 (LSD1/KDM1A) Inhibition as a Target for Disease Modification in Myelofibrosis. Cells 2022, 11, 2107
por: Gill, Harinder
Publicado: (2022)

Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
por: Beilner, Daniel, et al.
Publicado: (2020)

Lysine-Specific Demethylase 1 (LSD1) epigenetically controls osteoblast differentiation
por: Rummukainen, Petri, et al.
Publicado: (2022)

Lysine-Specific Demethylase 1 (LSD1/KDM1A) Contributes to Colorectal Tumorigenesis via Activation of the Wnt/Β-Catenin Pathway by Down-Regulating Dickkopf-1 (DKK1)
por: Huang, Zebin, et al.
Publicado: (2013)

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features
por: Speranzini, Valentina, et al.
Publicado: (2016)

A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1
por: Prusevich, Polina, et al.
Publicado: (2014)

Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells
por: Hino, Shinjiro, et al.
Publicado: (2016)

Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer
por: Majello, Barbara, et al.
Publicado: (2019)

Splicing- and demethylase-independent functions of LSD1 in zebrafish primitive hematopoiesis
por: Tamaoki, Junya, et al.
Publicado: (2020)

301 Inhibition of lysine-specific histone demethylase 1A (KDM1A/LSD1) attenuates DNA double strand break repair and enhances efficacy of temozolomide in glioblastoma
por: Alejo, Salvador, et al.
Publicado: (2023)

The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in Schizosaccharomyces pombe
por: Marayati, Bahjat F., et al.
Publicado: (2020)

Correction: Lysine-Specific Demethylase 1 (LSD1/KDM1A) Contributes to Colorectal Tumorigenesis via Activation of the Wnt/β-Catenin Pathway by Down-Regulating Dickkopf-1 (DKK1)
por: Huang, Zebin, et al.
Publicado: (2013)

Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors
por: Shi, Ying, et al.
Publicado: (2018)

Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis
por: Gahan, James M., et al.
Publicado: (2022)

Targeting Histone Demethylase LSD1 for Treatment of Deficits in Autism Mouse Models
por: Rapanelli, Maximiliano, et al.
Publicado: (2022)

Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition
por: Zeng, Cheng, et al.
Publicado: (2023)

Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study
por: Kong, Xiangqian, et al.
Publicado: (2011)

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex
por: Song, Yun, et al.
Publicado: (2020)

Ewing sarcoma resistance to SP-2509 is not mediated through KDM1A/LSD1 mutation
por: Pishas, Kathleen I., et al.
Publicado: (2018)

Somatic deletion of KDM1A/LSD1 gene is associated to advanced colorectal cancer stages
por: Ramírez-Ramírez, Ruth, et al.
Publicado: (2020)

Extracellular vesicles from human plasma for biomarkers discovery: Impact of anticoagulants and isolation techniques
por: Bettio, Valentina, et al.
Publicado: (2023)

Lysine-specific histone demethylase 1B (LSD2/KDM1B) represses p53 expression to promote proliferation and inhibit apoptosis in colorectal cancer through LSD2-mediated H3K4me2 demethylation
por: Cai, Shaoxin, et al.
Publicado: (2020)

Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex
por: Kim, Sang-Ah, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_0dhntt3qcv8sdhd7v9fpk3dtr4