Potential biomarkers uncovered by bioinformatics analysis in sotorasib resistant-pancreatic ductal adenocarcinoma

BACKGROUND: Mutant KRAS-induced tumorigenesis is prevalent in lung, colon, and pancreatic ductal adenocarcinomas. For the past 3 decades, KRAS mutants seem undruggable due to their high-affinity GTP-binding pocket and smooth surface. Structure-based drug design helped in the design and development o...

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Detalles Bibliográficos
Autores principales: Ramalingam, Prasanna Srinivasan, Priyadharshini, Annadurai, Emerson, Isaac Arnold, Arumugam, Sivakumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310804/
https://www.ncbi.nlm.nih.gov/pubmed/37396909
http://dx.doi.org/10.3389/fmed.2023.1107128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310804/
https://www.ncbi.nlm.nih.gov/pubmed/37396909
http://dx.doi.org/10.3389/fmed.2023.1107128

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