Single-cell RNA sequencing of neural stem cells derived from human trisomic iPSCs reveals the abnormalities during neural differentiation of Down syndrome

INTRODUCTION: Down syndrome (DS) is the most common genetic condition that causes intellectual disability in humans. The molecular mechanisms behind the DS phenotype remain unclear. Therefore, in this study, we present new findings on its molecular mechanisms through single-cell RNA sequencing. METH...

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Detalles Bibliográficos
Autores principales: Qiu, Jia-jun, Liu, Yan-na, Wei, Hao, Zeng, Fanyi, Yan, Jing-bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311021/
https://www.ncbi.nlm.nih.gov/pubmed/37396785
http://dx.doi.org/10.3389/fnmol.2023.1137123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311021/
https://www.ncbi.nlm.nih.gov/pubmed/37396785
http://dx.doi.org/10.3389/fnmol.2023.1137123

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