Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response

Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect is not satisfactory. Immune responsive gene 1 (IRG1) is a highly expressed gene in macrophage in response to inflammatory response and catalyzes the production of itaconate. Studies have rep...

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Detalles Bibliográficos
Autores principales: Yang, Wenchang, Wang, Yaxin, Wang, Tao, Li, Chengguo, Shi, Liang, Zhang, Peng, Yin, Yuping, Tao, Kaixiong, Li, Ruidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2022
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311025/
https://www.ncbi.nlm.nih.gov/pubmed/37397544
http://dx.doi.org/10.1016/j.gendis.2022.05.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311025/
https://www.ncbi.nlm.nih.gov/pubmed/37397544
http://dx.doi.org/10.1016/j.gendis.2022.05.039

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