Deletion of the first glycosylation site promotes Lassa virus glycoprotein-mediated membrane fusion

The Lassa virus (LASV) is endemic in West Africa and causes severe hemorrhagic Lassa fever in humans. The glycoprotein complex (GPC) of LASV is highly glycosylation-modified, with 11 ​N-glycosylation sites. All 11 N-linked glycan chains play critical roles in GPC cleavage, folding, receptor binding,...

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Detalles Bibliográficos
Autores principales: Dong, Siqi, Mao, Wenting, Liu, Yang, Jia, Xiaoying, Zhang, Yueli, Zhou, Minmin, Hou, Yuxia, Xiao, Gengfu, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311258/
https://www.ncbi.nlm.nih.gov/pubmed/37059226
http://dx.doi.org/10.1016/j.virs.2023.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311258/
https://www.ncbi.nlm.nih.gov/pubmed/37059226
http://dx.doi.org/10.1016/j.virs.2023.04.003

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