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Deletion of the first glycosylation site promotes Lassa virus glycoprotein-mediated membrane fusion
The Lassa virus (LASV) is endemic in West Africa and causes severe hemorrhagic Lassa fever in humans. The glycoprotein complex (GPC) of LASV is highly glycosylation-modified, with 11 N-glycosylation sites. All 11 N-linked glycan chains play critical roles in GPC cleavage, folding, receptor binding,...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Wuhan Institute of Virology, Chinese Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311258/ https://www.ncbi.nlm.nih.gov/pubmed/37059226 http://dx.doi.org/10.1016/j.virs.2023.04.003 |