KR4SL: knowledge graph reasoning for explainable prediction of synthetic lethality

MOTIVATION: Synthetic lethality (SL) is a promising strategy for anticancer therapy, as inhibiting SL partners of genes with cancer-specific mutations can selectively kill the cancer cells without harming the normal cells. Wet-lab techniques for SL screening have issues like high cost and off-target...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Ke, Wu, Min, Liu, Yong, Feng, Yimiao, Zheng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Biomedical Informatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311291/
https://www.ncbi.nlm.nih.gov/pubmed/37387166
http://dx.doi.org/10.1093/bioinformatics/btad261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311291/
https://www.ncbi.nlm.nih.gov/pubmed/37387166
http://dx.doi.org/10.1093/bioinformatics/btad261

Ejemplares similares