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KR4SL: knowledge graph reasoning for explainable prediction of synthetic lethality
MOTIVATION: Synthetic lethality (SL) is a promising strategy for anticancer therapy, as inhibiting SL partners of genes with cancer-specific mutations can selectively kill the cancer cells without harming the normal cells. Wet-lab techniques for SL screening have issues like high cost and off-target...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311291/ https://www.ncbi.nlm.nih.gov/pubmed/37387166 http://dx.doi.org/10.1093/bioinformatics/btad261 |