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Effects of spaced k-mers on alignment-free genotyping

MOTIVATION: Alignment-free, k-mer based genotyping methods are a fast alternative to alignment-based methods and are particularly well suited for genotyping larger cohorts. The sensitivity of algorithms, that work with k-mers, can be increased by using spaced seeds, however, the application of space...

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Detalles Bibliográficos
Autores principales: Häntze, Hartmut, Horton, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311327/
https://www.ncbi.nlm.nih.gov/pubmed/37387138
http://dx.doi.org/10.1093/bioinformatics/btad202