Cargando…

Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization

BACKGROUND: Inflammation and immune dysfunction with classically activated macrophages(M1) infiltration are important mechanisms in the progression of atherosclerosis (AS). Dynamin-related protein 1 (DRP1)-dependent mitochondrial fission is a novel target for alleviating inflammatory diseases. This...

Descripción completa

Detalles Bibliográficos
Autores principales:	Su, Ze-da-zhong, Li, Chun-qiu, Wang, Hua-wei, Zheng, Min-ming, Chen, Qing-wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311781/ https://www.ncbi.nlm.nih.gov/pubmed/37386574 http://dx.doi.org/10.1186/s12967-023-04270-9

Ejemplares similares

Mdivi-1 and mitochondrial fission: recent insights from fungal pathogens
por: Koch, Barbara, et al.
Publicado: (2019)

An Inhibitor of DRP1 (Mdivi-1) Alleviates LPS-Induced Septic AKI by Inhibiting NLRP3 Inflammasome Activation
por: Liu, Ruijin, et al.
Publicado: (2020)

Erratum to “An Inhibitor of DRP1 (Mdivi-1) Alleviates LPS-Induced Septic AKI by Inhibiting NLRP3 Inflammasome Activation”
por: Liu, Ruijin, et al.
Publicado: (2020)

The Non-Specific Drp1 Inhibitor Mdivi-1 Has Modest Biochemical Antioxidant Activity
por: Bordt, Evan A., et al.
Publicado: (2022)

Mdivi-1, mitochondrial fission inhibitor, impairs developmental competence and mitochondrial function of embryos and cells in pigs
por: YEON, Ji-Yeong, et al.
Publicado: (2014)

Insulin-stimulated lipid accumulation is inhibited by ROS-scavenging chemicals, but not by the Drp1 inhibitor Mdivi-1
por: Kim, Jung-Hak, et al.
Publicado: (2017)

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission
por: Wang, Qilong, et al.
Publicado: (2017)

Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis
por: Li, Yan-Hua, et al.
Publicado: (2019)

Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis
por: You, Yiran, et al.
Publicado: (2023)

Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis
por: Wang, Yating, et al.
Publicado: (2020)

PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons
por: Lee, Duk-shin, et al.
Publicado: (2018)

Evaluation of the efficacy of mitochondrial fission inhibitor (Mdivi-1) using non-alcoholic steatohepatitis (NASH) liver organoids
por: Elbadawy, Mohamed, et al.
Publicado: (2023)

The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1
por: Liu, Raymond, et al.
Publicado: (2015)

A role for septin 2 in Drp1‐mediated mitochondrial fission
por: Pagliuso, Alessandro, et al.
Publicado: (2016)

Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport
por: Ramonett, Aaron, et al.
Publicado: (2022)

Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling
por: Peiris-Pagès, Maria, et al.
Publicado: (2018)

Mdivi-1 Protects CD4(+) T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis
por: Wu, You, et al.
Publicado: (2019)

Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission
por: Rehklau, Katharina, et al.
Publicado: (2017)

ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1
por: Sonn, Seong Keun, et al.
Publicado: (2021)

Is Drp1 sufficient to catalyze membrane fission?
por: Roy, Krishnendu, et al.
Publicado: (2022)

Adrenergic Regulation of Drp1-Driven Mitochondrial Fission in Cardiac Physio-Pathology
por: Jhun, Bong Sook, et al.
Publicado: (2018)

DRP3 and ELM1 are required for mitochondrial fission in the liverwort Marchantia polymorpha
por: Nagaoka, Nagisa, et al.
Publicado: (2017)

Divide et Impera: Drp1-mediated Mitochondrial Fission in Glioma Malignancy
por: Eugenio-Pérez, Dianelena, et al.
Publicado: (2019)

DRP1-Mediated Mitochondrial Fission Regulates Lung Epithelial Response to Allergen
por: Bruno, Sierra R., et al.
Publicado: (2021)

Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria
por: Yang, Huan, et al.
Publicado: (2022)

Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway
por: Wang, Xisong, et al.
Publicado: (2018)

Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites
por: Ji, Wei-ke, et al.
Publicado: (2015)

TRAP1 Controls Mitochondrial Fusion/Fission Balance through Drp1 and Mff Expression
por: Takamura, Hironori, et al.
Publicado: (2012)

Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic/hypoxic injury by a mechanism independent of Drp1 GTPase activity
por: Duan, Chenyang, et al.
Publicado: (2020)

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
por: Otera, Hidenori, et al.
Publicado: (2010)

Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis
por: Li, Guobing, et al.
Publicado: (2014)

Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation
por: Yamamori, Tohru, et al.
Publicado: (2015)

Mitochondrial division inhibitor (mdivi-1) decreases oxidative metabolism in cancer
por: Dai, Wenting, et al.
Publicado: (2020)

Targeted up-regulation of Drp1 in dorsal horn attenuates neuropathic pain hypersensitivity by increasing mitochondrial fission
por: Zhang, Kun-Long, et al.
Publicado: (2021)

ERK/Drp1‐dependent mitochondrial fission contributes to HMGB1‐induced autophagy in pulmonary arterial hypertension
por: Feng, Wei, et al.
Publicado: (2021)

A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission
por: Macdonald, Patrick J., et al.
Publicado: (2014)

Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages
por: Kapetanovic, Ronan, et al.
Publicado: (2020)

The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α
por: Gao, Fushan, et al.
Publicado: (2021)

All-Trans Retinoic Acid Increases DRP1 Levels and Promotes Mitochondrial Fission
por: Chidipi, Bojjibabu, et al.
Publicado: (2021)

The uremic toxin hippurate promotes endothelial dysfunction via the activation of Drp1-mediated mitochondrial fission
por: Huang, Mengjie, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5g5hins2bfalb6r1d65fsr8olp