Hierarchical transcriptional network governing heterogeneous T cell exhaustion and its implications for immune checkpoint blockade

The fundamental principle of immune checkpoint blockade (ICB) is to protect tumor-infiltrating T cells from being exhausted. Despite the remarkable success achieved by ICB treatment, only a small group of patients benefit from it. Characterized by a hypofunctional state with the expression of multip...

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Detalles Bibliográficos
Autores principales: Tian, Weihong, Qin, Gaofeng, Jia, Miaomiao, Li, Wuhao, Cai, Weili, Wang, Hui, Zhao, Yangjing, Bao, Xuanwen, Wei, Wangzhi, Zhang, Yu, Shao, Qixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311999/
https://www.ncbi.nlm.nih.gov/pubmed/37398674
http://dx.doi.org/10.3389/fimmu.2023.1198551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311999/
https://www.ncbi.nlm.nih.gov/pubmed/37398674
http://dx.doi.org/10.3389/fimmu.2023.1198551

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