Cargando…
Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier
The blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders. Here, we demonstrate that the transport of human antibodie...
Autores principales: | Tien, Jason, Leonoudakis, Dmitri, Petrova, Ralitsa, Trinh, Vivian, Taura, Tetsuya, Sengupta, Debapriya, Jo, Lisa, Sho, Angela, Yun, Yong, Doan, Eric, Jamin, Anita, Hallak, Hussein, Wilson, David S., Stratton, Jennifer R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312019/ https://www.ncbi.nlm.nih.gov/pubmed/37381177 http://dx.doi.org/10.1080/19420862.2023.2229098 |
Ejemplares similares
-
Selection of bispecific antibodies with optimal developability using FcRn‑Ph‑HPLC as an optimized FcRn affinity chromatography method
por: Müller, Thomas, et al.
Publicado: (2023) -
Characterization of the Rabbit Neonatal Fc Receptor (FcRn) and Analyzing the Immunophenotype of the Transgenic Rabbits That Overexpresses FcRn
por: Catunda Lemos, Ana Paula, et al.
Publicado: (2012) -
The Role of FcRn in Antigen Presentation
por: Baker, Kristi, et al.
Publicado: (2014) -
Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics
por: Schoch, Angela, et al.
Publicado: (2015) -
Algorithmic multiscale analysis for the FcRn mediated regulation of antibody PK in human
por: Patsatzis, Dimitris G., et al.
Publicado: (2022)