Interrogating heterogeneity of cysteine-engineered antibody-drug conjugates and antibody-oligonucleotide conjugates by capillary zone electrophoresis-mass spectrometry

Production of site-specific cysteine-engineered antibody-drug conjugates (ADCs) in mammalian cells may produce developability challenges, fragments, and heterogenous molecules, leading to potential product critical quality attributes in later development stages. Liquid phase chromatography with mass...

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Detalles Bibliográficos
Autores principales: Xu, Tian, Zhang, Fan, Chen, Daoyang, Sun, Liangliang, Tomazela, Daniela, Fayadat-Dilman, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312020/
https://www.ncbi.nlm.nih.gov/pubmed/37381585
http://dx.doi.org/10.1080/19420862.2023.2229102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312020/
https://www.ncbi.nlm.nih.gov/pubmed/37381585
http://dx.doi.org/10.1080/19420862.2023.2229102

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