Rational repurposing, synthesis, in vitro and in silico studies of chromone-peptidyl hybrids as potential agents against Leishmania donovani

A chromone-peptidyl hybrids series was synthesised and rationally repurposed towards identification of potential antileishmanial hits against visceral leishmaniasis. Three hybrids 7c, 7n, and 7h showed potential IC(50) values (9.8, 10, and 12 µM, respectively) which were comparable to erufosine IC(5...

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Detalles Bibliográficos
Autores principales: Hassan, Ahmed H. E., Bayoumi, Waleed A., El-Sayed, Selwan M., Phan, Trong-Nhat, Kim, Yeon Ju, Lee, Chae Hyeon, Cho, Soo Bin, Oh, Taegeun, Ham, Gyeongpyo, Mahmoud, Kazem, No, Joo Hwan, Lee, Yong Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312039/
https://www.ncbi.nlm.nih.gov/pubmed/37381756
http://dx.doi.org/10.1080/14756366.2023.2229071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312039/
https://www.ncbi.nlm.nih.gov/pubmed/37381756
http://dx.doi.org/10.1080/14756366.2023.2229071

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