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Heterogeneity in functional genetic screens: friend or foe?

Functional genetic screens to uncover tumor-intrinsic nodes of immune resistance have uncovered numerous mechanisms by which tumors evade our immune system. However, due to technical limitations, tumor heterogeneity is imperfectly captured with many of these analyses. Here, we provide an overview of...

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Detalles Bibliográficos
Autores principales: Vredevoogd, David W., Peeper, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312307/
https://www.ncbi.nlm.nih.gov/pubmed/37398651
http://dx.doi.org/10.3389/fimmu.2023.1162706