Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells

Male mice lacking the androgen receptor (AR) in pancreatic b cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide-1 (GLP-1) insulinotropic action. Here, we examined the archi...

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Detalles Bibliográficos
Autores principales: Xu, Weiwei, Qadir, M.M. Fahd, Nasteska, Daniela, de Sa, Paula Mota, Gorvin, Caroline M., Blandino-Rosano, Manuel, Evans, Charles R., Ho, Thuong, Potapenko, Evgeniy, Veluthakal, Rajakrishnan, Ashford, Fiona B., Bitsi, Stavroula, Fan, Jia, Bhondeley, Manika, Song, Kejing, Sure, Venkata N., Sakamuri, Siva S.V.P., Schiffer, Lina, Beatty, Wandy, Wyatt, Rachael, Frigo, Daniel E., Liu, Xiaowen, Katakam, Prasad V., Arlt, Wiebke, Buck, Jochen, Levin, Lonny R., Hu, Tony, Kolls, Jay, Burant, Charles F., Tomas, Alejandra, Merrins, Matthew J., Thurmond, Debbie C., Bernal-Mizrachi, Ernesto, Hodson, David J., Mauvais-Jarvis, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312392/
https://www.ncbi.nlm.nih.gov/pubmed/37200193
http://dx.doi.org/10.1016/j.celrep.2023.112529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312392/
https://www.ncbi.nlm.nih.gov/pubmed/37200193
http://dx.doi.org/10.1016/j.celrep.2023.112529

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