Dynamical modelling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity

Phenotypic heterogeneity of melanoma cells contributes to drug tolerance, increased metastasis, and immune evasion in patients with progressive disease. Diverse mechanisms have been individually reported to shape extensive intra- and inter- tumoral phenotypic heterogeneity, such as IFNγ signaling an...

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Detalles Bibliográficos
Autores principales: Subhadarshini, Seemadri, Sahoo, Sarthak, Debnath, Shibjyoti, Somarelli, Jason A., Jolly, Mohit Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312429/
https://www.ncbi.nlm.nih.gov/pubmed/37398358
http://dx.doi.org/10.1101/2023.01.09.523355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312429/
https://www.ncbi.nlm.nih.gov/pubmed/37398358
http://dx.doi.org/10.1101/2023.01.09.523355

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