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14-3-3 phosphorylation inhibits 14-3-3θ’s ability to regulate LRRK2 kinase activity
LRRK2 mutations are among the most common genetic causes for Parkinson’s disease (PD), and toxicity is associated with increased kinase activity. 14-3-3 proteins are key interactors that regulate LRRK2 kinase activity. Phosphorylation of the 14-3-3θ isoform at S232 is dramatically increased in human...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312468/ https://www.ncbi.nlm.nih.gov/pubmed/37398189 http://dx.doi.org/10.1101/2023.05.27.542591 |