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14-3-3 phosphorylation inhibits 14-3-3θ’s ability to regulate LRRK2 kinase activity

LRRK2 mutations are among the most common genetic causes for Parkinson’s disease (PD), and toxicity is associated with increased kinase activity. 14-3-3 proteins are key interactors that regulate LRRK2 kinase activity. Phosphorylation of the 14-3-3θ isoform at S232 is dramatically increased in human...

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Detalles Bibliográficos
Autores principales:	Pattanayak, Rudradip, Petit, Chad M., Yacoubian, Talene A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312468/ https://www.ncbi.nlm.nih.gov/pubmed/37398189 http://dx.doi.org/10.1101/2023.05.27.542591

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