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Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization

The heterochromatin protein 1 (HP1) family is a crucial component of heterochromatin with diverse functions in gene regulation, cell cycle control, and cell differentiation. In humans, there are three paralogs, HP1α, HP1β, and HP1γ, which exhibit remarkable similarities in their domain architecture...

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Detalles Bibliográficos
Autores principales: Phan, Tien M., Kim, Young C., Debelouchina, Galia T., Mittal, Jeetain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312469/
https://www.ncbi.nlm.nih.gov/pubmed/37398008
http://dx.doi.org/10.1101/2023.05.28.542535