Tuning methylation-dependent silencing dynamics by synthetic modulation of CpG density

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Methylation of cytosines in CG dinucleotides (CpGs) within promoters has been shown to lead to gene silencing in mammals in natural contexts. Recently, engineered recruitment of methyltransferases (DNMTs) at specific loci was shown to be sufficient to silence synthetic and endogenous gene expression...

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Detalles Bibliográficos
Autores principales: Ma, Yitong, Budde, Mark W., Zhu, Junqin, Elowitz, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312471/
https://www.ncbi.nlm.nih.gov/pubmed/37398290
http://dx.doi.org/10.1101/2023.05.30.542205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312471/
https://www.ncbi.nlm.nih.gov/pubmed/37398290
http://dx.doi.org/10.1101/2023.05.30.542205

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