Biochemical, biomarker, and behavioral characterization of the Grn(R493X) mouse model of frontotemporal dementia

Heterozygous loss-of-function mutations in the progranulin gene (GRN) are a major cause of frontotemporal dementia due to progranulin haploinsufficiency; complete deficiency of progranulin causes neuronal ceroid lipofuscinosis. Several progranulin-deficient mouse models have been generated, includin...

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Detalles Bibliográficos
Autores principales: Smith, Denise M., Aggarwal, Geetika, Niehoff, Michael L., Jones, Spencer A., Banerjee, Subhashis, Farr, Susan A., Nguyen, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312473/
https://www.ncbi.nlm.nih.gov/pubmed/37398305
http://dx.doi.org/10.1101/2023.05.27.542495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312473/
https://www.ncbi.nlm.nih.gov/pubmed/37398305
http://dx.doi.org/10.1101/2023.05.27.542495

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