Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve

We previously described a process referred to as transmitophagy where mitochondria shed by retinal ganglion cell (RGC) axons are transferred to and degraded by surrounding astrocytes in the optic nerve head of mice. Since the mitophagy receptor Optineurin (OPTN) is one of few large-effect glaucoma g...

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Detalles Bibliográficos
Autores principales: Jeong, Yaeram, Davis, Chung-ha O., Muscarella, Aaron M., Deshpande, Viraj, Kim, Keun-Young, Ellisman, Mark H., Marsh-Armstrong, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312487/
https://www.ncbi.nlm.nih.gov/pubmed/37398269
http://dx.doi.org/10.1101/2023.05.26.542507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312487/
https://www.ncbi.nlm.nih.gov/pubmed/37398269
http://dx.doi.org/10.1101/2023.05.26.542507

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