Universal features of Nsp1-mediated translational shutdown by coronaviruses

Nonstructural protein 1 (Nsp1) produced by coronaviruses shuts down host protein synthesis in infected cells. The C-terminal domain of SARS-CoV-2 Nsp1 was shown to bind to the small ribosomal subunit to inhibit translation, but it is not clear whether this mechanism is broadly used by coronaviruses,...

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Detalles Bibliográficos
Autores principales: Schubert, Katharina, Karousis, Evangelos D., Ban, Ivo, Lapointe, Christopher P., Leibundgut, Marc, Bäumlin, Emilie, Kummerant, Eric, Scaiola, Alain, Schönhut, Tanja, Ziegelmüller, Jana, Puglisi, Joseph D., Mühlemann, Oliver, Ban, Nenad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312502/
https://www.ncbi.nlm.nih.gov/pubmed/37398176
http://dx.doi.org/10.1101/2023.05.31.543022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312502/
https://www.ncbi.nlm.nih.gov/pubmed/37398176
http://dx.doi.org/10.1101/2023.05.31.543022

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