Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells

Endoplasmic reticulum (ER) retention of mis-folded glycoproteins is mediated by the ERlocalised eukaryotic glycoprotein secretion checkpoint, UDP-glucose glycoprotein glucosyl-transferase (UGGT). The enzyme recognises a mis-folded glycoprotein and flags it for ER retention by reglucosylating one of...

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Detalles Bibliográficos
Autores principales: Tax, Gábor, Guay, Kevin P., Soldà, Tatiana, Hitchman, Charlie J., Hill, Johan C., Vasiljević, Snežana, Lia, Andrea, Modenutti, Carlos P., Straatman, Kees R., Santino, Angelo, Molinari, Maurizio, Zitzmann, Nicole, Hebert, Daniel N., Roversi, Pietro, Trerotola, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312515/
https://www.ncbi.nlm.nih.gov/pubmed/37398215
http://dx.doi.org/10.1101/2023.05.30.542711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312515/
https://www.ncbi.nlm.nih.gov/pubmed/37398215
http://dx.doi.org/10.1101/2023.05.30.542711

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