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The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force

The mitotic spindle is the bipolar, microtubule-based structure that segregates chromosomes at each cell division. Aberrant spindles are frequently observed in cancer cells, but how oncogenic transformation affects spindle mechanics and function, particularly in the mechanical context of solid tumor...

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Detalles Bibliográficos
Autores principales: Sutanto, Renaldo, Neahring, Lila, Marques, Andrea Serra, Kilinc, Seda, Goga, Andrei, Dumont, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312523/
https://www.ncbi.nlm.nih.gov/pubmed/37398487
http://dx.doi.org/10.1101/2023.05.30.542893